Abstract
CHROMATOGRAPHY1 has been used to show2–5 that exogenous high molecular weight DNA disappears rapidly from the blood of mice injected intravenously. These results confirm those of Tsumita and Iwanaga6, based on the Schneider procedure, and also show that the high molecular weight DNA disappears much more rapidly than the low molecular weight DNA. At the same time, labelled DNA could be found in certain organs, and it was tentatively assumed that the labelled molecules appearing in those tissues corresponded to the injected ones. In order to ascertain the nature of these compounds, we have used ultracentrifugation in caesium chloride gradients and different bacterial DNAs.
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LEDOUX, L., CHARLES, P. & SRÖGL, M. Fate of Exogenous DNA in Blood and Hyperplastic Genital Tract of Female Mice. Nature 214, 1241–1243 (1967). https://doi.org/10.1038/2141241a0
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DOI: https://doi.org/10.1038/2141241a0
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