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Serum Antinuclear Factor and the Influence of Environment in Mice

Nature volume 214, pages 1136–1138 (1967)Cite this article

Abstract

SYSTEMIC lupus erythematosus in man has been regarded as a classic autoimmune disorder1, and its clinical and pathological features have been associated with the occurrence of certain autoantibodies. A thymic abnormality in the disease was originally postulated by Burnet2, and was confirmed recently by Burnet and Mackay3. This finding established in systemic lupus erythematosus., like myasthenia gravis, the association between a clinical disorder, serum autoantibodies and a thymic change.

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References

  1. Holborow, E. J., in Clinical Aspects of Immunology (edit. by Gell, P. G. H., and Coombs, R. R. A.) (Blackwell, Oxford, 1963).

    Google Scholar 

  2. Burnet, F. M., Austral. Ann. Med., 11, 79 (1962).

    Article  CAS  Google Scholar 

  3. Burnet, F. M., and Mackay, I. R., J. Path. Bact., 89, 263 (1965).

    Article  CAS  Google Scholar 

  4. Bielchowsky, M., Helyer, B. J., and Howie, J. B., Proc. Univ. Otago Med. School, 37, 9 (1959).

    Google Scholar 

  5. Long, G., Holmes, M. C., and Burnet, F. M., Austral. J. Exp. Biol., 41, 315 (1963).

    Article  CAS  Google Scholar 

  6. Holborow, E. J., Barnes, R. D. S., and Tuffrey, M., Nature, 207, 601 (1965).

    Article  ADS  CAS  Google Scholar 

  7. Helyer, B. J., and Howie, J. B., Lancet, ii, 1026 (1963).

  8. Hill, A., J. Inst. Animal Tech., 17, 133 (1966).

    Google Scholar 

  9. Norins, L. C., and Holmes, M. C., Immunology, 93, 148 (1964).

    CAS  Google Scholar 

  10. Friou, G. F., and Teague, P. O., J. Lab. Clin. Med., 62, 875 (1963).

    Google Scholar 

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Authors and Affiliations

  1. Department of Haematology, Institute of Child Health, Guilford Street, London, W.C.1

    R. D. BARNES & MAUREEN TUFFREY

Authors
  1. R. D. BARNES
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  2. MAUREEN TUFFREY
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BARNES, R., TUFFREY, M. Serum Antinuclear Factor and the Influence of Environment in Mice. Nature 214, 1136–1138 (1967). https://doi.org/10.1038/2141136a0

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