Letter | Published:

Subcellular Distribution of Norepinephrine in Uteri of Some Species

Naturevolume 214pages108109 (1967) | Download Citation

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Abstract

THE response of the uterus to catecholamines shows considerable variability from species to species as well as within the same species1,2. Thus, norepinephrine has been reported to relax the uterus of non-pregnant rats and to contract the uterus of the gravid rat2. The mechanism of these variations has not yet been elucidated. Recently it has been reported that rat uterus shows cyclic variation in epinephrine concentration3 and in uptake of tritiated epinephrine4. In contrast to heart, brain and other tissues, most of the epinephrine and norepinephrine in the rat uterus was found in the soluble fraction5 (70 per cent). It seemed of interest, therefore, to compare the subcellular distribution of endogenous CA in uteri of various species in order to evaluate the possible relationship of this distribution to the variation in uterine responses to catecholamines.

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References

  1. 1

    Levy, B., and Ahlquist, R. P., in Drill's Pharmacology in Medicine, third ed. (edit. by DiPalma, J. R.), 474 (McGraw-Hill, New York, 1965).

  2. 2

    Greeff, K., and Holtz, P., Arch. Int. Pharmacodyn., 88, 228 (1951).

  3. 3

    Rudzik, A. D., and Miller, J. W., J. Pharmacol. Exp. Therap., 138, 88 (1962).

  4. 4

    Wurtman, R. J., Chu, E. E., and Axelrod, J., Nature, 198, 547 (1963).

  5. 5

    Wurtman, R. J., Axelrod, J., and Potter, L. T., J. Pharmacol. Exp. Therap., 144, 150 (1964).

  6. 6

    Kahane, Z., and Vestergaard, P., J. Lab. Clin. Med., 65, 848 (1965).

  7. 7

    Oskarsson, V., Acta. Endocrinol., 34, 38 (1960).

  8. 8

    Miller, M. D., and Marshall, J. M., Amer. J. Physiol., 209, 859 (1965).

  9. 9

    Musacchio, J. M., Kopin, I. J., and Weise, V. K., J. Pharmacol. Exp. Therap., 148, 22 (1965).

  10. 10

    Campos, H. A., Stitzel, R. E., and Shideman, F. E., J. Pharmacol. Exp., Therap., 141, 290 (1963).

  11. 11

    Neff, N. H., Tozer, T. N., Hammer, W., and Brodie, B. B., Life Sciences, 4, 1869 (1965).

  12. 12

    Brown, L., Proc. Roy. Soc., B, 162, 1 (1965).

  13. 13

    Thoenen, A., Hurlimann, A., and Haefeby, W., Experientia, 19, 601 (1963).

  14. 14

    Weil-Malherbe, H., and Posner, H. S., J. Pharmacol. Exp. Therap., 140, 93 (1963).

  15. 15

    Green, R. D., and Miller, J. W., J. Pharmacol. Exp. Therap., 152, 42 (1966).

  16. 16

    Farrant, J., Brit. J. Pharmacol., 20, 540 (1963).

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    • Y. GUTMAN

    Present address: Department of Pharmacology, The Hebrew University—Hadassah Medical School, Jerusalem, Israel

Affiliations

  1. Clinical Neuropharmacology Research Center, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C.

    • Y. GUTMAN
    •  & H. WEIL-MALHERBE

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https://doi.org/10.1038/214108a0

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