Letter | Published:

Effects of Gastrin and its Analogues on Isolated Smooth Muscles

Naturevolume 214pages105107 (1967) | Download Citation



STIMULATION of smooth muscle is one of several physiological activities of natural gastrin that are shared by the C-terminal tetrapeptide sequence Try-Met-Asp-Phe-NH2 and other structurally related peptides1. The stimulation by gastrin I and gastrin II of tone and motility of a denervated fundic pouch in a conscious dog is inhibited by atropine2. Stimulation of gastrointestinal motility in man by gastrin is also diminished by atropine3. Contractions of the isolated ileum of guinea-pig are probably mediated by stimulation of postganglionic parasympathetic nerves, leading to the liberation of acetylcholine4.

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  1. Department of Pharmacology, Royal College of Surgeons, Lincoln's Inn Fields, London, W.C.2

    •  & J. R. VANE


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