Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Effects of Gastrin and its Analogues on Isolated Smooth Muscles

Nature volume 214, pages 105–107 (1967)Cite this article

Abstract

STIMULATION of smooth muscle is one of several physiological activities of natural gastrin that are shared by the C-terminal tetrapeptide sequence Try-Met-Asp-Phe-NH2 and other structurally related peptides1. The stimulation by gastrin I and gastrin II of tone and motility of a denervated fundic pouch in a conscious dog is inhibited by atropine2. Stimulation of gastrointestinal motility in man by gastrin is also diminished by atropine3. Contractions of the isolated ileum of guinea-pig are probably mediated by stimulation of postganglionic parasympathetic nerves, leading to the liberation of acetylcholine4.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Gregory, R. A., and Tracy, H. J., Nature, 204, 935 (1964).

    Article  ADS  Google Scholar 

  2. Gregory, R. A., and Tracy, H. J., Gut, 5, 103 (1964).

    Article  CAS  Google Scholar 

  3. Smith, A. N., and Hogg, D., Lancet, i, 403 (1966).

  4. Bennett, A., Nature, 208, 170 (1965).

    Article  ADS  CAS  Google Scholar 

  5. Gaddum, J. H., Brit. J. Pharmacol. Chemother., 8, 321 (1953).

    Article  CAS  Google Scholar 

  6. Vane, J. R., Brit. J. Pharmacol. Chemother., 23, 360 (1964).

    Article  CAS  Google Scholar 

  7. Paton, W. D. M., J. Physiol., 137, 35 (1957).

    Google Scholar 

  8. Morley, J. S., Tracy, H. J., and Gregory, R. A., Nature, 207, 1356 (1965).

    Article  ADS  CAS  Google Scholar 

  9. Gaddum, J. H., and Picarelli, Z. P., Brit. J. Pharmacol. Chemother., 12, 323 (1957).

    Article  CAS  Google Scholar 

  10. Vane, J. R., Brit. J. Pharmacol. Chemother., 12, 344 (1957).

    Article  CAS  Google Scholar 

  11. Day, M., and Vane, J. R., Brit. J. Pharmacol. Chemother., 20, 150 (1963).

    Article  CAS  Google Scholar 

  12. Paton, W. D. M., and Vane, J. R., J. Physiol., 165, 10 (1963).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacology, Royal College of Surgeons, Lincoln's Inn Fields, London, W.C.2

    EMILIA MIKOS & J. R. VANE

Authors
  1. EMILIA MIKOS
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. R. VANE
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

MIKOS, E., VANE, J. Effects of Gastrin and its Analogues on Isolated Smooth Muscles. Nature 214, 105–107 (1967). https://doi.org/10.1038/214105a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/214105a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing