Letter | Published:

Lymphoblastoid Transformation of Lymphocytes in vitro after Microwave Irradiation

Naturevolume 214pages102103 (1967) | Download Citation



IT is well established that lymphocytes grown with various added substances in vitro can transform into cells resembling blastoid forms (lymphoblastoid transformation)1,2 or macrophages (lymphoid macrophages)3,4. The added compounds can be classed as unspecific, including phytohaemagglutinin (PHA) and streptolysin A, and specific, such as tuberculin and diphtheria toxoids5; lymphocytes can also transform when incubated with allogenic cells6,7.

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  1. 1

    Elves, M., Lancet, ii, 1131 (1965).

  2. 2

    Lycette, R., and Pearmain, G., Lancet, i, 434 (1965).

  3. 3

    Gough, J., Elves, M., and Israels, M., Exp. Cell Res., 38, 476 (1965).

  4. 4

    Ostrowski, K., Czerski, P., Barańska, W., and Rymaszewska, T., in Proc. Tenth Cong. Europ. Soc. Haematol. (Karger, Basle, in the press).

  5. 5

    Cooper, H., and Rubin, A., Lancet, ii, 723 (1965).

  6. 6

    Bach, F., and Hirschhorn, K., Science, 143, 813 (1964).

  7. 7

    Bain, B., and Lovenstein, L., Blood, 23, 108 (1964).

  8. 8

    Czerski, P., Szmigielski, S., and Litwin, J., Vox Sang., 11, 724 (1966).

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  1. Department of Histology and Embryology, Warsaw University Medical School



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