Influence of Protracted Infusion of Glucose and Insulin on the Composition and Regeneration Activity of Liver after Partial Hepatectomy in Rats

Abstract

IN the liver tissue which remains after partial hepatectomy (resection of 65–70 per cent of the liver) marked changes in the composition and the energy metabolism1,2 develop even before the occurrence of increased mitotic activity. The energy metabolism in the liver tissue is shifted from a predominant utilization of glycides to an increased utilization of lipids3 with a corresponding decrease in the content of glycogen and an increase in the content of lipids. We wished to find out whether the regenerative activity of the liver would be affected if the development of these changes was arrested.

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ŠIMEK, J., CHMELAŘ, V., MĚLKA, J. et al. Influence of Protracted Infusion of Glucose and Insulin on the Composition and Regeneration Activity of Liver after Partial Hepatectomy in Rats. Nature 213, 910–911 (1967). https://doi.org/10.1038/213910a0

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