Abstract
INDUCTION of neoplasms in newborn hamsters by the injection of adenovirus type 12 has been well established1–4. This virus has been found primarily in “normal” humans and then only infrequently5. The data presented here on the inoculation of immature baboons with adenovirus type 12 were obtained from a study designed to ascertain whether or riot this virus would produce tumours. In order to enhance the oncogenic potential of the virus, thymectomy and splenectomy, irradiation and an immunosuppressive drug (‘Imuran’: 6-(1-methyl-4-nitro-5-imidazolyl) thiopurine) were used either singly or in combination.
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References
Trentin, J. J., Yabe, Y., and Taylor, G., Proc. Amer. Assoc. Cancer Res., 3, 369 (1962).
Trentin, J. J., Yabe, Y., and Taylor, G., Science, 137, 835 (1962).
Yabe, Y., Trentin, J. J., and Taylor, G., Proc. Soc. Exp. Biol. and Med., 111, 343 (1962).
Huebner, R. J., Rowe, W. P., and Lance, W. T., Proc. U.S. Nat. Acad. Sci., 48, 2051 (1962).
Rowe, W. P., Huebner, R. J., and Bell, T. A., Ann. N.Y. Acad. Sci., 67, 255 (1957).
Vice, T. E., and Rodriguez, A. R., in Proc. First Int. Symp. on the Baboon and its Use as an Experimental Animal (edit. by Vagtborg, H.), 125 (University of Texas Press, Austin, 1965).
Hummer, R. L., in Proc. Second Int. Symp. on the Baboon and its Use as an Experimental Animal (1965).
Ratner, I. A., Vice, T. E., Britton, H., Rodriguez, A. R., and Kalter, S. S., in Proc. Second Int. Symp. on the Baboon and its Use as an Experimental Animal (1965).
Kalter, S. S., Procedures for Routine Laboratory Diagnosis of Virus and Rickettsial Diseases (Burgess Publishing Co., Minneapolis, Minn., 1963).
Stanley, N. F., and Leak, P. J., Nature, 199, 1309 (1963).
East, J., Parrot, D. M. V., Chesterman, F. C., and Pomerance, A., J. Exp. Med., 118, 1069 (1963).
Leyten, R., DeSomer, P., Denys, jun., P., and Prinzie, A., Antonie van Leuwenhoek J. Micro. and Serology, 31, 145 (1965).
Miller, J. F. A. P., Science, 144, 544 (1964).
Britton, H. A., Vice, T. E., Ratner, I. A., Kalter, S. S., Rodriguez, A. R., and Berchelmann, M. L., Proc. Second Int. Symp. on the Baboon and its Use as an Experimental Animal (1965).
Parrott, D. M. V., and East, J., Nature, 207, 487 (1965).
Cross, A. M., Davies, A. J. S., Doe, B., and Leuchars, E., Nature, 203, 1239 (1964).
Mori, R., Nomoto, K., and Takeya, K., Proc. Japan Acad., 40, 445 (1964).
Takeya, K., Mori, R., and Nomoto, K., Proc. Japan Acad., 40, 769 (1964).
Takeya, K., Mori, R., and Nomoto, K., Proc. Japan Acad., 40, 572 (1964).
Law, L., Science, 147, 164 (1965).
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KALTER, S., RATNER, I., BRITTON, H. et al. Wasting Syndrome in Thymectomized Immature Baboons (Papio Species) after Infection with Adenovirus Type 12. Nature 213, 610–612 (1967). https://doi.org/10.1038/213610a0
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DOI: https://doi.org/10.1038/213610a0
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