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UGA: A Third Nonsense Triplet in the Genetic Code

Abstract

Two base triplets of the genetic code are known not to represent any amino-acid. It now appears that, in Escherichia coli, the UGA triplet of the bases uracil, guanine and adenine does not code for an amino-acid and is therefore also a “nonsense triplet”.

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References

  1. 1

    For the structure of the genetic code and the evidence for nonsense triplets see the papers in the Cold Spring Harbor Symposium XXXI on “The Genetic Code”, 1966 (in the press).

  2. 2

    Weigert, M. G., Lanka, E., and Garen, A., J. Mol. Biol., 23, 391 (1967).

    CAS  Article  Google Scholar 

  3. 3

    Sarabhai, A., and Brenner, S. in preparation.

  4. 4

    Barnett, L., Brenner, S., Crick, F. H. C., Shulman, R. G., and Watts-Tobin, R. J., Phil. Trans. Roy. Soc. (in the press).

  5. 5

    Brenner, S., Stretton, A. O. W., and Kaplan, S., Nature, 206, 994 (1965).

    ADS  CAS  Article  Google Scholar 

  6. 6

    Benzer, S., and Champe, S. P., Proc. U.S. Nat. Acad. Sci., 48, 1114 (1962).

    ADS  CAS  Article  Google Scholar 

  7. 7

    Morgan, A. R., Wells, R. D., and Khorana, H. G., Proc. U.S. Nat. Acad.Sci. (in the press).

  8. 8

    Crick, F. H. C., J. Mol. Biol., 19, 548 (1966).

    CAS  Article  Google Scholar 

  9. 9

    Brenner, S., and Beckwith, J. R., J. Mol. Biol., 13, 629 (1965).

    Article  Google Scholar 

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BRENNER, S., BARNETT, L., KATZ, E. et al. UGA: A Third Nonsense Triplet in the Genetic Code. Nature 213, 449–450 (1967). https://doi.org/10.1038/213449a0

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