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Growth Regulatory Effects of Cellular Interaction


Euploid human fibroblasts and amnion cells showed contact inhibition of growth in monolayers. In mixed cultures the two cell types did not inhibit each other. Neither inhibited the growth of aneuploid epithelial cells. What is the significance of these phenomena with regard to the growth of malignant tumours ?

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EAGLE, H., LEVINE, E. Growth Regulatory Effects of Cellular Interaction. Nature 213, 1102–1106 (1967).

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