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Growth Regulatory Effects of Cellular Interaction

Abstract

Euploid human fibroblasts and amnion cells showed contact inhibition of growth in monolayers. In mixed cultures the two cell types did not inhibit each other. Neither inhibited the growth of aneuploid epithelial cells. What is the significance of these phenomena with regard to the growth of malignant tumours ?

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References

  1. 1

    Abercrombie, M. M., Heaysman, J. E. M., and Karthauser, H. M., Exp. Cell Res., 13, 276 (1957).

    CAS  Article  Google Scholar 

  2. 2

    Abercrombie, M., and Heaysman, E. M., Exp. Cell Res., 6, 293 (1954).

    CAS  Article  Google Scholar 

  3. 3

    Abercrombie, M., and Ambrose, E. J., Cancer Res., 22, 525 (1962).

    CAS  PubMed  Google Scholar 

  4. 4

    Levine, E. M., Becker, Y., Boone, C. W., and Eagle, H., Proc. U.S. Nat. Acad. Sci., 53, 350 (1965).

    ADS  CAS  Article  Google Scholar 

  5. 5

    Eagle, H., Washington, C., and Friedman, S. M., Proc. U.S. Nat. Acad. Sci., 56, 126 (1966).

    ADS  Article  Google Scholar 

  6. 6

    Eagle, H., Science, 130, 432 (1959).

    ADS  CAS  Article  Google Scholar 

  7. 7

    Oyama, V. I., and Eagle, H., Proc. Soc. Exp. Biol. and Med., 91, 305 (1956).

    CAS  Article  Google Scholar 

  8. 8

    Barski, G., and Béléhradek, jun., J., Exp. Cell Res., 37, 464 (1965).

    CAS  Article  Google Scholar 

  9. 9

    Stoker, M., Virology, 24, 165 (1964).

    CAS  Article  Google Scholar 

  10. 9a

    Stoker, M. G. P., Shearer, M., and O'Neill, C., J. Cell Sci., 1, 297 (1966).

    CAS  PubMed  Google Scholar 

  11. 10

    Moscona, A. A., J. Cell. Comp. Physiol., 60, suppl. 1, 65 (1962).

    Article  Google Scholar 

  12. 11

    Moscona, A. A., Eighteenth Symposium, Society for the Study of Development and Growth, 45 (Ronald Press Co., New York, 1960).

    Google Scholar 

  13. 12

    Weiss, P., Fifth Canadian Cancer Conference, 5, 241 (1963).

    Google Scholar 

  14. 13

    Grover, J. W., Dev. Biol., 3, 555 (1961).

    CAS  Article  Google Scholar 

  15. 14

    Steinberg, M. S., Proc. U.S. Nat. Acad. Sci., 48, 1577 (1962).

    ADS  CAS  Article  Google Scholar 

  16. 15

    Trinkaus, J. P., and Lentz, J. P., Dev. Biol., 9, 115 (1964).

    CAS  Article  Google Scholar 

  17. 16

    Vogt, M., and Dulbecco, R., Proc. U.S. Nat. Acad. Sci., 46, 356 (1960).

    ADS  Article  Google Scholar 

  18. 17

    Coman, D. R., Cancer Res., 4, 625 (1944).

    Google Scholar 

  19. 18

    Coman, D. R., Cancer Res., 13, 397 (1953).

    CAS  PubMed  Google Scholar 

  20. 19

    Halpern, B., Pejsachowicz, B., Febvre, H. L., and Barski, G., Nature, 209, 157 (1966).

    ADS  CAS  Article  Google Scholar 

  21. 20

    Pejsachowicz, B., Halpern, B., Febvre, H., and Barski, G., C.R. Acad. Sci., Paris, 259, 4891 (1964).

    CAS  Google Scholar 

  22. 21

    Foley, G. E., and Handler, A. H., Proc. Soc. Exp. Biol. and Med., 94, 661 (1957).

    CAS  Article  Google Scholar 

  23. 22

    Foley, G. E., and Handler, A. H., Ann. N.Y. Acad. Sci., 76, 506 (1958).

    ADS  CAS  Article  Google Scholar 

  24. 23

    Foley, G. E., Handler, A. H., Adams, R. A., and Craig, J. M., Nat. Cancer Inst. Monograph, 7, Symposium: Analytical Cell Culture, 11, 173 (1962).

    CAS  Google Scholar 

  25. 24

    Todaro, G. J., and Green, H., J. Cell Biol., 17, 299 (1963).

    CAS  Article  Google Scholar 

  26. 25

    Defendi, V., Lehman, J., and Kraemer, P., Virology, 19, 592 (1963).

    CAS  Article  Google Scholar 

  27. 26

    Todaro, G. J., Lazar, G. K., and Green, H., J. Cell. Comp. Physiol., 66, 325 (1966).

    Article  Google Scholar 

  28. 27

    Kruse, P., and Miedema, E., J. Cell Biol., 27, 273 (1965).

    Article  Google Scholar 

  29. 28

    Boveri, T., Verhandl. Physikol-med. Gesellschaft Wiirzburg., 35, 67 (1902). Reprinted in Foundations of Exp. Embryol. (edit. by Willier, B. H., and Oppenheimer, J. M.) (Prentice-Hall, Englewood Cliffs, N.J., 1964).

    Google Scholar 

Download references

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EAGLE, H., LEVINE, E. Growth Regulatory Effects of Cellular Interaction. Nature 213, 1102–1106 (1967). https://doi.org/10.1038/2131102a0

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