Letter | Published:

Interference not mediated by Interferon

Naturevolume 212page540 (1966) | Download Citation



AUTOINTERFERENCE or autoinhibition is the phenomenon in which reduced multiplication of a virus results when a host is inoculated with a high concentration of virus. It has often been encountered in tissue culture cells with animal viruses. Members of the myxoviruses and arboviruses groups provide many examples1–4. These viruses can also induce interferon in the cells they infect. Interferon can be demonstrated in undiluted or low dilutions of culture fluids infected with virus used as inocula. Autointerference, therefore, has usually been attributed to the presence of interferon carried along with the inoculum. The present communication deals with an example of autointerference which results from the infection of chick embryo (CE) cells by Western equine encephalomyelitis (WEE) virus. The results showed that interferon was not involved in this instance.

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  1. 1

    Von Magnus, P., Acta Pathol. Microbiol. Scand., 28, 278 (1951).

  2. 2

    Cooper, P. D., and Bellett, A. J. D., J. Gen. Microbiol., 21, 485 (1959).

  3. 3

    Chambers, V. C., Virology, 3, 62 (1957).

  4. 4

    Lockart, B. Z., Virology, 10, 198 (1960).

  5. 5

    Lockart, R. Z., J. Bact., 85, 556 (1963).

  6. 6

    Dulbecco, R., and Vogt, M., J. Exp. Med., 99, 183 (1954).

  7. 7

    Taylor, J., Biochem. Biophys. Res. Commun., 14, 447 (1964).

  8. 8

    Lockart, R. Z., Biochem. Biophys. Res. Commun., 15, 513 (1964).

  9. 9

    Hackett, A. J., Virology, 24, 51 (1964).

  10. 10

    Sreevalsan, T., and Lockart, R. Z. (unpublished observations).

  11. 11

    Mussgay, M., and Rott, R., Virology, 23, 573 (1964).

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  1. Department of Microbiology, University of Texas, Austin, Texas

    •  & R. Z. LOCKART


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