Letter | Published:

Nerve Endings isolated from Rats convulsed by Methionine Sulphoximine

Nature volume 212, pages 537538 (29 October 1966) | Download Citation

Subjects

Abstract

METHIONINE sulphoximine (MSO) is a toxic agent frequently used to produce experimental convulsions in various laboratory animals. These seizures are similar to human epilepsy, and several findings have pointed toward a possible biochemical mechanism of the convulsant1–3. Peters and Tower4 found a marked inhibition of glutamine synthesis in brain slices and a specific inhibition of glutamine synthetase has been observed5,6. In spite of these physiological and neurochemical changes, a morphological correlate for the action of MSO has not been found7.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    , in Temporal Lobe Epilepsy, 301 (Charles C. Thomas, Springfield, Illinois, 1958).

  2. 2.

    , in Neurochemistry of Epilepsia (Charles C. Thomas, Springfield, Illinois, 1960).

  3. 3.

    , and , in Neurochemistry, 649 (Charles C. Thomas, Springfield, Illinois, 1962).

  4. 4.

    , and , J. Neurochem., 5, 80 (1959).

  5. 5.

    , and , Biochem. Pharmacol., 12, 989 (1963).

  6. 6.

    , and , Biochem. Pharmacol., 13, 489 (1965).

  7. 7.

    , and , in Temporal Lobe Epilepsy, 288 (Charles C. Thomas, Springfield, Illinois, 1958).

  8. 8.

    , , , and , J. Neurochem., 9, 23 (1962).

  9. 9.

    , , , , and , J. Neurochem., 10, 225 (1963).

  10. 10.

    Unpublished results.

  11. 11.

    , and , Life Sci., 2, 85 (1963).

  12. 12.

    , and , J. Neurochem., 12, 287 (1965).

  13. 13.

    , Histophysiology of Synapses and Neurosecretion (Pergamon Press, London, 1964).

  14. 14.

    , and , Biophys. Biochem. Cytol., 3, 611 (1957).

Download references

Author information

Affiliations

  1. Instituto de Anatomía General y Embriología, Facultad de Medicina, Universidad de Buenos Aires, Argentina.

    • E. DE ROBERTIS
    • , GEORGINA RODRIGUEZ DE LORES ARNAIZ
    •  & O. Z. SELLINGER

Authors

  1. Search for E. DE ROBERTIS in:

  2. Search for GEORGINA RODRIGUEZ DE LORES ARNAIZ in:

  3. Search for O. Z. SELLINGER in:

About this article

Publication history

Published

DOI

https://doi.org/10.1038/212537a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.