Letter | Published:

Membranous Cytoplasmic Spirals in Dilantin Intoxication

Naturevolume 212pages536537 (1966) | Download Citation



THE efficacy of diphenylhydantoin (dilantin) in the treatment of certain epileptic conditions is well established1. The earlier paper of Merritt and Putnam2 indicated that excessive doses of dilantin can produce ataxia in human beings, although this is a rare finding. Recently, Kokenge et al.3, following the earlier study of Utterback4, showed severe losses of Purkinje cells in the cerebellum of rats and cats given toxic doses of dilantin. In the present investigations toxic doses of dilantin were given to rats and the ultrastructural changes occurring during Purkinje cell degeneration were studied. In addition, an especially peculiar phenomenon of membrane hyperplasia was observed in Purkinje cells with an apparent resistance to the drug.

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  1. 1

    Yahr, M. D., and Merritt, H. H., J. Amer. Med. Assoc., 161, 333 (1956).

  2. 2

    Merritt, H. H., and Putnam, T. J., J. Amer. Med. Assoc., 111, 1068 (1938).

  3. 3

    Kokenge, R., Kutt, H., and McDowell, F., Neurology, 15, 823 (1965).

  4. 4

    Utterback, R. A., Djeman, R., and Malek, J., J. Neuropath., 17, 516 (1958).

  5. 5

    Gonatas, N. K., and Gonatas, J., J. Neuropath. Exp. Neurol., 24, 318 (1965).

  6. 6

    Wallace, B. J., Volk, B., and Lazarus, S. S., Arch. Pathol., 80, 466 (1965).

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  1. Center for Brain Research, University of Rochester, Rochester, New York



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