Abstract
THE mechanism of cellular proliferation following tissue injury is unclear. Cytochemical and biochemical investigations have shown that the onset of mitotic activity in injured tissues is preceded by an early regressive phase when ribonucleoprotein and RNA are affected1. Clear structural changes in the ergastoplasm of rat liver have been observed in the first hours after partial hepatectomy2,3. These changes are accompanied by a sharp decrease in the ability of RNA to bind basic dyes3. There are also some data indicating that the injury induced changes in RNA may be due to an activation of latent RNA degrading enzymes1,4. Ribosomes from different sources are known to contain a latent RNase which can be activated under the influence of different agents5–7. Another RNA degrading enzyme, a phosphodiesterase, was also found in the microsomal fraction8.
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BELTCHEV, B., TSANEV, R. Ribonucleic Acid Degrading Activity of Rat Liver Microsomes following Partial Hepatectomy. Nature 212, 531–532 (1966). https://doi.org/10.1038/212531b0
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DOI: https://doi.org/10.1038/212531b0
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