Letter | Published:

Hyperoxia and the Intravascular Volumes of Tissues in the Growing Rat

Naturevolume 212page523 (1966) | Download Citation



THE period of rapid myelination in central nervous development is immediately preceded by a rapid increase in oxygen utilization by the brain1. This is accompanied by a phase of rapid growth of capillaries and arterioles in the central nervous tissue2–4. By injecting dye Gyllensten3 has recently shown that prolonged exposure to 90–100 per cent oxygen reduced the growth of new capillaries in the mouse brain during this stage of development.

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    McIlwain, H., in Biochemistry and the CNS, 179 (Churchill, London, 1955).

  2. 2

    Rhodes, A. J., and Hyde, J. B., Growth, 29, 173 (1965).

  3. 3

    Gyllensten, L., Acta Morphol. Neerl.-Scand., 2, 289 (1959).

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    Craigie, E. H., J. Comp. Neurol., 39, 301 (1925).

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    Mollison, P. L., and Veall, N., Brit. J. Haematol., 1, 62 (1955).

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    Trappitt, A., Quart. J. Exp. Physiol., 49, 310 (1964).

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    Oeff, K., and Konig, A., Arch. Exp. Path. Pharmakol., 226, 98 (1955).

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    Nair, V., Palm, D., and Roth, L. J., Nature, 188, 497 (1960).

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  1. Paediatric Research Unit, Guy's Hospital Medical School, London, S.E.1

    •  & R. G. SPECTOR


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