Letter | Published:

Systolic Blood Pressure in Eight Inbred Strains of Mice

Nature volume 212, pages 519520 (29 October 1966) | Download Citation

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Abstract

IT has been demonstrated that genetic factors determine to some degree the blood pressure of rats1–3 and mice4. During the course of development of inbred strains, genes affecting blood pressure and all other traits are fixed within a strain and the strains may show differences because of the random fixation of these genes. Strains of mice with relatively low or high blood pressures are potentially useful in physiological investigations, as the genetic variability affecting the trait would be controlled within a strain. The present work was undertaken to characterize eight inbred strains of mice of diverse genetic origin with respect to systolic blood pressure.

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Author information

Affiliations

  1. The Jackson Laboratory, Bar Harbor, Maine.

    • GUNTHER SCHLAGER

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DOI

https://doi.org/10.1038/212519a0

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