Letter | Published:

Glycamino Substances in Human Brain

Naturevolume 212pages509510 (1966) | Download Citation



DURING the course of studies on the more comprehensive extraction of brain proteins with neutral aqueous buffers1 it was noted that appreciable quantities of material soluble in organic solvents were extracted together at the same time2. Some of this non-dialysable material was found to have the mobility on thin layer chromatography of perfectly free, unattached and identifiable lipid compounds. On the other hand, several substances staining as lipids in this material were observed on thin layer chromatography. These were distinguished from any known brain lipids by their markedly lower mobilities. Seven of these previously unrecognized substances have now been isolated, and, because of their content of carbohydrate and amino groups, have been called glycamino substances pending complete structural identification.

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  1. Foundation for Research on the Nervous System and Boston University School of Medicine, Boston



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