Letter | Published:

Effect of Thrombin, Adenosine Diphosphate, Connective Tissue, and Endotoxin on Platelet Glycolysis

Naturevolume 212page508 (1966) | Download Citation



THROMBIN, which aggregates platelets, also induces an increase in rate of platelet glycolysis1,2. Other substances capable of aggregating platelets include adenosine diphosphate (ADP)3, connective tissue4, and (in rabbit platelet systems) endotoxin5. I have compared these other aggregating substances with thrombin in their ability to influence platelet glycolysis as measured by the production of lactate.

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  1. 1

    Bettex-Galland, M., and Luscher, E. F., Thromb. Diath. Haemorrh., 4, 178 (1960).

  2. 2

    Corn, M., J. App. Physiol. (in the press).

  3. 3

    Gaarder, A., Jonsen, J., Laland, S., Hellem, A., and Owren, P. A., Nature, 192, 531 (1961).

  4. 4

    Zucker, M. B., and Borelli, J., Proc. Soc. Exp. Biol. and Med., 109, 779 (1962).

  5. 5

    Horowitz, H. I., Des Prex, R. M., and Hook, E. W., J. Exp. Med., 116, 619 (1962).

  6. 6

    Barker, S. B., Standard Methods of Clinical Chemistry, 3, 167 (Academic Press, New York, 1961).

  7. 7

    Kaser-Glanzmann, R., and Luscher, E., Thromb. Diath. Haemorrh., 7, 480 (1982).

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  1. Department of Medicine, George Washington University, D.C. General Hospital, Washington, D.C.



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