Letter | Published:

Haemoglobin Association and the Sigmoid Oxygen Equilibrium Curve

Naturevolume 212page506 (1966) | Download Citation

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Abstract

REDUCED haemoglobin is generally considered to have the same molecular weight as oxyhaemoglobin. The osmotic pressure measurements of Adair1 and the light scattering experiments of Rossi-Fanelli, Antonini and Caputo2 agree with this concept, but our light scattering measurements have shown that reduced horse haemoglobin is in a state of close association when in 0.1 molar phosphate (pH 7.4).

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References

  1. 1

    Adair, G. S., Proc. Roy. Soc., A, 120, 573 (1928).

  2. 2

    Rossi-Fanelli, A., Antonini, E., and Caputo, A., J. Biol. Chem., 236, 391 (1961).

  3. 3

    Hill, A. V., J. Physiol., 40, Proc. IV (1910).

  4. 4

    Douglas, C. G., Haldane, J. S., and Haldane, J. B. S., J. Physiol., 44, 275 (1912).

  5. 5

    Briehl, R. W., J. Biol. Chem., 238, 2361 (1963).

  6. 6

    Roughton, F. J. W., Biochem. J., 95, 58 (1965).

  7. 7

    Otis, A. B., and Roughton, F. J. W., Proc. Roy. Soc., B, 144, 55 (1955).

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Affiliations

  1. Laboratory of Biochemistry I, University of Louvain, Belgium

    • P. PUTZEYS
    •  & H. REIJNAERS

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https://doi.org/10.1038/212506a0

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