Abstract
REDUCED haemoglobin is generally considered to have the same molecular weight as oxyhaemoglobin. The osmotic pressure measurements of Adair1 and the light scattering experiments of Rossi-Fanelli, Antonini and Caputo2 agree with this concept, but our light scattering measurements have shown that reduced horse haemoglobin is in a state of close association when in 0.1 molar phosphate (pH 7.4).
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References
Adair, G. S., Proc. Roy. Soc., A, 120, 573 (1928).
Rossi-Fanelli, A., Antonini, E., and Caputo, A., J. Biol. Chem., 236, 391 (1961).
Hill, A. V., J. Physiol., 40, Proc. IV (1910).
Douglas, C. G., Haldane, J. S., and Haldane, J. B. S., J. Physiol., 44, 275 (1912).
Briehl, R. W., J. Biol. Chem., 238, 2361 (1963).
Roughton, F. J. W., Biochem. J., 95, 58 (1965).
Otis, A. B., and Roughton, F. J. W., Proc. Roy. Soc., B, 144, 55 (1955).
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PUTZEYS, P., REIJNAERS, H. Haemoglobin Association and the Sigmoid Oxygen Equilibrium Curve. Nature 212, 506 (1966). https://doi.org/10.1038/212506a0
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DOI: https://doi.org/10.1038/212506a0
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