Abstract
CEPHALOTHIN, a newly developed semi-synthetic antibiotic, has a β-lactam dihydrothiazine ring system as a molecular nucleus. The similarity of its structural formula to that of penicillin G (PC-G) suggests that cephalothin (CET) may obtain antigenicity through irreversible covalent bonding to proteins, as occurs with PC-G.
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SHIBATA, K., ATSUMI, T., HORIUCHI, Y. et al. Immunological Cross-reactivities of Cephalothin and its Related Compounds with Benzylpenicillin (Penicillin G). Nature 212, 419–420 (1966). https://doi.org/10.1038/212419a0
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DOI: https://doi.org/10.1038/212419a0
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