Letter | Published:

Generalized Skeletal Response to Local Injuries—a Part of Wide Mesenchymal Reaction

Naturevolume 212pages410411 (1966) | Download Citation



IN previous investigations1–3, it was found that a systemic metabolic skeletal response was elicited by local injury caused by mechanical force, heat, cold, an electric current, ultrasound and ionizing radiations. This reaction is thought to be a part of a mechanism to signalize the occurrence of damage, inducing a reparative response which tends to normalize relations in the damaged area, and which radiates into the skeleton as a whole. Our hypothesis was that this reaction takes place primarily in the organic matter of bone, and because of this the metabolic aberrations are reflected not only in the organic, but also in the mineral, part of bone tissue.

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  1. 1

    Kolář, J., and Babický, A., Nature, 192, 1297 (1961); 195, 1107 (1962).

  2. 2

    Kolář, J., Babický, A., Káclová, J., and Kácl, J., Nature, 202, 411 (1964).

  3. 3

    Kolář, J., Babický, A., and Vrabeý, R., The Physical Agents and Bone (Czechoslovak Academy of Sciences, Prague, 1965).

  4. 4

    Novák, L., Pospíšil, M., and Hošek, B., Folia Biol., 11, 147 (1965).

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  1. Isotope Laboratories, Biological Institutes of the Czech Academy of Sciences, Prague, Czechoslovakia



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