Letter | Published:

Cholinesterase Inhibitory Property of Dimethyl Sulphoxide

Nature volume 212, page 405 (22 October 1966) | Download Citation

Subjects

Abstract

DIMETHYL sulphoxide (DMSO) has long been known for its solvent properties and its ability to prevent freezing damage to living cells1. More recently, it has been found to cross intact cellular membranes and the skin very readily and to effect rapid penetration through these tissues of some substances dissolved in it2,3. Despite these remarkable abilities, very few undesirable effects in either experimental animals4 or in man have been reported. As a result, DMSO is coming into rather widespread use as therapy for a number of human diseases5.

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References

  1. 1.

    , and , Nature, 183, 1394 (1959).

  2. 2.

    , , , and , Fed. Proc., 23, 410 (1964).

  3. 3.

    , and , Arch. Derm., 90, 512 (1964).

  4. 4.

    , , and , Toxicol. and App. Pharm., 7, 104 (1965).

  5. 5.

    , , and , J. Amer. Med. Assoc., 192, 309 (1965).

  6. 6.

    , and , Z. Physiol. Chem., 210, 33 (1932).

  7. 7.

    , and , The Pharmacological Basis of Therapeutics (Macmillan, New york, 1956).

  8. 8.

    , J. Biol. Chem., 180, 249 (1949).

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Author information

Affiliations

  1. Dermatology Research Section, Research and Development Service, Letterman General Hospital, San Francisco, California.

    • W. MITCHELL SAMS JUN.
    •  & NICHOLAS V. CARROLL

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https://doi.org/10.1038/212405a0

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