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Cholinesterase Inhibitory Property of Dimethyl Sulphoxide

Naturevolume 212page405 (1966) | Download Citation



DIMETHYL sulphoxide (DMSO) has long been known for its solvent properties and its ability to prevent freezing damage to living cells1. More recently, it has been found to cross intact cellular membranes and the skin very readily and to effect rapid penetration through these tissues of some substances dissolved in it2,3. Despite these remarkable abilities, very few undesirable effects in either experimental animals4 or in man have been reported. As a result, DMSO is coming into rather widespread use as therapy for a number of human diseases5.

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    Rosenbaum, E. E., Herschler, R. J., and Jacob, S. W., J. Amer. Med. Assoc., 192, 309 (1965).

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  1. Dermatology Research Section, Research and Development Service, Letterman General Hospital, San Francisco, California



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