Letter | Published:

Prediction and Demonstration of Iron Chelating Ability of Sugars

Naturevolume 212pages404405 (1966) | Download Citation



FRUCTOSE is capable of forming a highly stable chelate complex with iron, in contrast to some other hexose sugars and disaccharides which have little or no such ability1. Recently, attention has been focused on the iron–fructose complex because of its ability to move across biological membranes2 and to enhance gastrointestinal iron absorption in man3. The structure which has been proposed for this compound is one in which iron, incorporated into a five-membered ring, is bound through the hydroxyl and carbonyl oxygen atoms to carbon atoms one and two of the fructose molecule1,4.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Charley, P. J., Sarkar, B., Stitt, C. F., and Saltman, P., Biochim. Biophys. Acta, 69, 313 (1963).

  2. 2

    Stitt, C., Charley, P. J., Butt, E. M., and Saltman, P., Proc. Soc. Exp. Biol. and Med., 110, 70 (1962).

  3. 3

    Davis, P. S., and Deller, D. J., Aust. Ann. Med. (in the press).

  4. 4

    Aasa, R., Malmström, B., Saltman, P., and Vänngård, T., Biochim. Biophys. Acta, 80, 430 (1964).

Download references

Author information


  1. Department of Medicine, University of Adelaide, Australia

    •  & D. J. DELLER


  1. Search for PETER S. DAVIS in:

  2. Search for D. J. DELLER in:

About this article

Publication history

Issue Date



Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.