Letter | Published:

Alterations in Protein Fractions of Heated Blood Serum

Nature volume 212, page 396 (22 October 1966) | Download Citation



WHEN blood serum is heated by being placed in boiling water the proteins coagulate and denaturation occurs. Such proteins do not migrate on paper electrophoresis. On the other hand, serum proteins subjected to temperatures higher than body temperature but lower than boiling point migrate in different ways depending on the temperature. Denaturation of proteins consists, essentially, of the cleavage of some cross-links between peptide chains. Heat denaturation is caused by the excessive thermal agitation of the peptide chains and the resulting cleavage of hydrogen bonds.

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  1. Institute of Biochemistry, University of Istanbul.

    • S. TEKMAN
    •  & N. ÖNER


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