Letter | Published:

Alterations in Protein Fractions of Heated Blood Serum

Nature 212, 396 (1966) | Download Citation

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Abstract

WHEN blood serum is heated by being placed in boiling water the proteins coagulate and denaturation occurs. Such proteins do not migrate on paper electrophoresis. On the other hand, serum proteins subjected to temperatures higher than body temperature but lower than boiling point migrate in different ways depending on the temperature. Denaturation of proteins consists, essentially, of the cleavage of some cross-links between peptide chains. Heat denaturation is caused by the excessive thermal agitation of the peptide chains and the resulting cleavage of hydrogen bonds.

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References

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    Van der Scheer, J., Wyckoff, R. W. G., and Clarke, F. L., J. Immunol., 40, 39 (1941).

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    Bozzetti, E., and Prina, C., Boll. Soc. Ital. Biol. Sper., 31, 953 (1955).

  3. 3

    Tekman, S., Istanbul Tip Fak. Mec., 28, 85 (1965).

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    Durrum, E. L., J. Amer. Chem. Soc., 72, 2943 (1950).

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  1. Institute of Biochemistry, University of Istanbul

    • S. TEKMAN
    •  & N. ÖNER

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https://doi.org/10.1038/212396a0

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