Letter | Published:

Nuclear Blebs in the Cells of the Guinea-pig Thymus

Nature volume 212, pages 315317 (15 October 1966) | Download Citation

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Abstract

THE thymus is known to contain a very high concentration of DNA and to play a large part in lymphopoiesis. Recently, the hypothesis has been developed that the thymus not only produces new thymocytes but also confers immunobiological competence on them and that these cells, carried to other lymphatic organs via the blood stream, become the primordial cells of clones which give rise to generations of immunologically competent cells. On this basis, thymocytes develop their immunobiological properties within the thymus—that is, they differentiate there. Because the differentiation involves the synthesis of new proteins, nucleic acids therefore have a substantial role; for this reason the phenomena taking place in the nucleus deserve special attention.

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Author information

Affiliations

  1. Department of Histology and Embryology, Medical University, Budapest, Hungary.

    • I. TÖRŐ
    •  & I. OLÁH

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https://doi.org/10.1038/212315a0

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