Letter | Published:

Effect of Chlorpromazine and Other Drugs on the Disposition of Circulating Melatonin

Nature volume 212, page 312 (15 October 1966) | Download Citation

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Abstract

THE mammalian pineal gland has the unique ability to synthesize methoxyindoles such as melatonin1,2 and methoxytryptophol3. It has been suggested that these compounds function as hormones4,5: melatonin is secreted into the circulation4,6 and efficiently extracted from the blood by most tissues7,8; both compounds inhibit gonad function4,5,9, and it has also been claimed that melatonin acts on the thyroid10,11, gut12, pituitary13, skin14 and brain15.

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Affiliations

  1. National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.

    • R. J. WURTMAN
    •  & J. AXELROD

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https://doi.org/10.1038/212312a0

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