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Structures of the Polymyxins A and the Question of Identity with the Polymyxins M

Naturevolume 212page311 (1966) | Download Citation

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Abstract

THE elucidation of the structures of the polymyxins and the related antibiotic circulin A has so far revealed a remarkable consistency. Polymyxins B1 and B2 (refs. 1 and 2), polymyxins E1 and E2 (identical with colistins A and B, respectively)3,4, and circulin A (ref. 5) are now known to be cyclic decapeptides, each possessing a ring of seven amino-acids and a chain of three amino-acids attached to the ring at the α-amino-group of an αγ-diaminobutyric (DAB) acid component. As shown in the accompanying formula, differences occur in the nature of the accompanying aliphatic acid and of certain amino-acid constituents.

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References

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    Suzuki, T., Hayashi, K., Fujikawa, K., and Tsukamoto, K., J. Biochem. (Japan), 54, 555 (1963); 56, 335 (1964).

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    Suzuki, T., Hayashi, K., Fujikawa, K., and Suketa, Y., Experientia, 21, 307 (1965).

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  1. The Wellcome Research Laboratories, Beckenham, Kent

    • S. WILKINSON
    •  & L. A. LOWE

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https://doi.org/10.1038/212311a0

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