Letter | Published:

Chemical Characteristics of Leptotrichia buccalis Endotoxin

Nature volume 212, pages 301302 (15 October 1966) | Download Citation

Subjects

Abstract

WE recently reported1 that washed, killed suspensions of Leptotrichia buccalis were lethal to rabbits on intravenous injection. Endotoxin, which possesses potent biological activity2,3, was extracted from L. buccalis with hot phenol according to the technique of Westphal and Lüderitz4. Further purification was accomplished by differential centrifugation.

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Author information

Author notes

    • R. L. GUSTAFSON

    Present address: Abbott Laboratories, North Chicago, Illinois.

Affiliations

  1. Department of Microbiology, University of Illinois at the Medical Center, Chicago, Illinois.

    • R. L. GUSTAFSON
    • , A. V. KROEGER
    •  & E. M. K. VAICHULIS

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DOI

https://doi.org/10.1038/212301a0

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