Abstract
WE recently reported1 that washed, killed suspensions of Leptotrichia buccalis were lethal to rabbits on intravenous injection. Endotoxin, which possesses potent biological activity2,3, was extracted from L. buccalis with hot phenol according to the technique of Westphal and Lüderitz4. Further purification was accomplished by differential centrifugation.
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References
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GUSTAFSON, R., KROEGER, A. & VAICHULIS, E. Chemical Characteristics of Leptotrichia buccalis Endotoxin. Nature 212, 301–302 (1966). https://doi.org/10.1038/212301a0
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DOI: https://doi.org/10.1038/212301a0
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