Letter | Published:

Cobalt-free Corrinoids as Vitamin B12 Antagonists

Naturevolume 212pages300301 (1966) | Download Citation



CORRINOID compounds containing no metal have recently been found in certain species of photosynthetic bacteria1,2. Hitherto, the corrin ring has not been obtained without a central metal atom. Several “metal free” corrinoids of different electrophoretic mobilities have been purified from these bacteria. They are converted into yellow products of unknown structure by the action of light, alkali or acid. They take up cobalt in slightly alkaline solution. We have now tested these compounds as antagonists of vitamin B12 in some bioassay systems. This communication describes the results of these tests.

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  1. D. PERLMAN: Fellow, John Simon Guggenheim Memorial Foundation, 1966.


  1. The Squibb Institute for Medical Research, New Brunswick, New Jersey

    • D. PERLMAN
    •  & J. I. TOOHEY
  2. Department of Cell Physiology, University of California, Berkeley, California

    • D. PERLMAN
    •  & J. I. TOOHEY


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