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Metabolic Intermediates in Skeletal Muscles with Fast and Slow Rates of Post-mortem Glycolysis

Abstract

STUDIES on the rate-limiting steps of glycolysis have been carried out in dog1, mouse2 and frog3 skeletal muscle and in perfused rat heart4, yeast5 and ascites tumour cells6. The rate of post-mortem anaerobic glycolysis is extremely variable in porcine striated musculature7. Study of metabolic intermediates associated with the extremes in glycolytic rate (fast, pH < 5.5, and slow, pH > 6.0 by 1 hour post mortem) may provide information on the control of anaerobic glycolysis in intact skeletal muscle.

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KASTENSCHMIDT, L., BRISKEY, E. & HOEKSTRA, W. Metabolic Intermediates in Skeletal Muscles with Fast and Slow Rates of Post-mortem Glycolysis. Nature 212, 288–289 (1966). https://doi.org/10.1038/212288a0

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