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Capacity of Pepsin-digested Antibody to inhibit Antibody Formation

Naturevolume 212pages208209 (1966) | Download Citation



THE capacity of passively administered serum antibody to inhibit specific antibody formation1 has suggested that serum antibody may act as a type of “feedback” mechanism2–5. It is not known whether this effect of antibody results from its interaction with antigen or from a “direct” effect of some kind on the antibody-producing cells themselves5. A “direct” effect might be mediated by the Fc fragment of antibody, because this fragment, which does not contain the combining sites for antigen, is known to be essential for many other biological functions of antibody, such as complement fixation6, combination with skin7 and passage across the placenta8. The purpose of our experiments was to determine whether this fragment of the antibody gamma-globulin plays a part in the inhibition by antibody of specific antibody formation.

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  1. 1

    Smith, T., J. Exp. Med., 11, 241 (1909).

  2. 2

    Uhr, J. W., and Baumann, J., J. Exp. Med., 113, 935 (1961).

  3. 3

    Sahiar, K., and Schwartz, R. S., Science, 145, 395 (1964).

  4. 4

    Möller, G., Transplantation, 2, 405 (1964).

  5. 5

    Rowley, D. A., and Fitch, F. W., J. Exp. Med., 120, 987 (1964).

  6. 6

    Taranta, A., and Franklin, E. C., Science, 134, 1981 (1961).

  7. 7

    Franklin, E. C., and Ovary, Z., Immunology, 6, 434 (1963).

  8. 8

    Brambell, F. W. R., Hemmings, W. A., Oakley, C. L., and Porter, R. R., Proc. Roy. Col., London, Series B, 151, 478 (1960).

  9. 9

    Adams, M. H., in Bacteriophages (Interscience Publishers, New York, 1959).

  10. 10

    Uhr, J. W., and Finkelstein, M. S., J. Exp. Med., 117, 457 (1963).

  11. 11

    Nisonoff, A., Wissler, F. C., Lipman, L. N., and Woernly, D. L., Arch. Biochem. Biophys., 89, 230 (1960).

  12. 12

    Lowry, O. H., Rosebrough, N. J., Farr, L., and Randall, R. J., J. Biol. Chem., 193, 265 (1951).

  13. 13

    Uhr, J. W., and Weissmann, G., J. Immunol., 94, 544 (1965).

  14. 14

    Finkelstein, M. S., and Uhr, J. W., Science, 146, 67 (1964).

  15. 15

    Spiegelberg, H. L., and Weigle, W. O., J. Exp. Med., 121, 323 (1965).

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    Present address: Department of Pathology, Harvard Medical School, Boston, Massachusetts


  1. Irvington House Institute and Department of Medicine, New York University School of Medicine, New York

    •  & JONATHAN W. UHR


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