Abstract
ADMINISTRATION of excess of vitamin D causes significant histological changes in tissues of man and experimental animals. These changes lead to massive metastatic calcification1–3. The mechanism underlying the metastatic calcification found in hypervitaminosis D is at present obscure. This metastatic calcification may be related in part to increases in blood calcium and inorganic phosphate induced by calciferol. The mechanism of metastatic calcification also appears to involve some primary biochemical lesions in soft tissue, however, due to the direct action of vitamin D on these tissues.
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SPIRICHEV, V., BLAZHEVICH, N. Inhibitory Effect of Vitamin D2 on Adenosine-triphosphatase Activity. Nature 212, 203–204 (1966). https://doi.org/10.1038/212203a0
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DOI: https://doi.org/10.1038/212203a0
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