Letter | Published:

Acceleration of Enzyme Reactions in Ice

Naturevolume 212page194 (1966) | Download Citation



FREEZING is widely used by biologists and chemists for the purpose of slowing or stopping reactions. In the past few years we and others have shown that freezing can accelerate a number of catalysed reactions, including hydrolysis, aminolysis, dehydration, oxidation arid peroxide decomposition1–7.

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  1. 1

    Grant, N. H., Clark, D. E., and Alburn, H. E., J. Amer. Chem. Soc., 83, 4476 (1961).

  2. 2

    Prusoff, W. H., Biochim. Biophys. Acta, 68, 302 (1963).

  3. 3

    Bruice, T. C., and Butler, A. R., J. Amer. Chem. Soc., 86, 4104 (1964).

  4. 4

    Alburn, H. E., and Grant, N. H., J. Amer. Chem. Soc., 87, 4174 (1965).

  5. 5

    Grant, N. H., and Alburn, H. E., Biochemistry, 4, 1913 (1965).

  6. 6

    Grant, N. H., and Alburn, H. E., Science, 150, 1589 (1965).

  7. 7

    Grant, N. H., and Alburn, H. E., Arch. Biochem. Biophys. (in the press).

  8. 8

    Sussman, M. V., and Chin, L., Science, 151, 324 (1966).

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  1. Research Division, Wyeth Laboratories, Radnor, Pennsylvania

    • N. H. GRANT
    •  & H. E. ALBURN


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