Letter | Published:

N-Amidino-3,5-diamino-6-chloropyrazine-carboxamide : an Active Diuretic in the Carboxamide Series

Nature volume 212, pages 191193 (08 October 1966) | Download Citation

Subjects

Abstract

SINCE the initial observation that steroidal hormones from the adrenal cortex promote renal conservation of sodium was made some forty years ago, it has been demonstrated that aldosterone is the most potent sodium-retaining hormone produced by the adrenal cortex1,2. A marked increase in the secretion of aldosterone has been associated with nephrosis, liver cirrhosis, toxaemia of pregnancy and congestive heart failure3–5.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    , Metabolism, 5, 369 (1956).

  2. 2.

    , and , Arch. Intern. Med., 102, 314 (1958).

  3. 3.

    , , and , J. Clin. Endocrinol. and Metabolism, 15, 621 (1955).

  4. 4.

    , Amer. J. Med., 21, 423 (1956).

  5. 5.

    , Amer. J. Med., 29, 486 (1960).

  6. 6.

    , and , Proc. Soc. Exp. Biol. and Med. (in the press).

  7. 7.

    , , , , and (in preparation).

  8. 8.

    , , and (in preparation).

  9. 9.

    , Metabolism Clin. and Exp., 10, 1021 (1961).

  10. 10.

    , , , and , Proc. Soc. Exp. Biol. and Med., 100, 625 (1959).

  11. 11.

    , , , and , Clin. Res., 7, 66 (1959).

  12. 12.

    , Evaluation of Drug Activities: Pharmacometrics, 2, 752 (Academic Press, London, 1964).

  13. 13.

    , and , in Progress in Drug Research, edit. by Jucker, E., 2, 9 (Interscience Publishers Inc., New York, 1960).

Download references

Author information

Affiliations

  1. Merck Institute for Therapeutic Research, Rahway, New Jersey.

    • M. S. GLITZER
    •  & S. L. STEELMAN

Authors

  1. Search for M. S. GLITZER in:

  2. Search for S. L. STEELMAN in:

About this article

Publication history

Published

DOI

https://doi.org/10.1038/212191a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.