Letter | Published:

Diffusion Potentials across the Small Intestine

Naturevolume 212pages189190 (1966) | Download Citation



THE spontaneous potential difference across the wall of the small intestine is small compared with that found across most other epithelial tissues. The intestine is unique, however, in that the magnitude of the potential difference is considerably enhanced by the presence of actively transferred hexoses and amino-acids1,2. In the case of the amino-acids it has been suggested that the increase might be accounted for by a modification of passive ionic permeabilities at the mucosal face of the intestine. These experiments were undertaken to investigate permeability characteristics of the rat small intestine and to determine whether they can be modified by an actively transferred hexose.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Barry, R. J. C., Dikstein, S., Matthews, J., Smyth, D. H., and Wright, E. M., J. Physiol., 171, 316 (1964).

  2. 2

    Baillien, M., and Schoffeniels, E., Arch. Internat. Physiol. Biochim., 70, 140 (1962).

  3. 3

    Robinson, J. R., Biochem. J., 45, 68 (1949).

  4. 4

    Baillien, M., and Schoffeniels, E., Biochim. Biophys. Acta, 53, 537 (1961).

  5. 5

    Hodgkin, A. L., and Katz, B., J. Physiol., 108, 37 (1949).

  6. 6

    Goldman, D. E., J. Gen. Physiol., 27, 37 (1943).

Download references

Author information

Author notes

    • E. M. WRIGHT

    Present address: The Biophysical Laboratory, Harvard Medical School, Boston


  1. Department of Physiology, University of Sheffield

    • E. M. WRIGHT


  1. Search for E. M. WRIGHT in:

About this article

Publication history

Issue Date



Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.