Abstract
MANY products of catecholamine metabolism have been identified, but the metabolic fate of epinephrine and norepinephrine has remained virtually unknown1,2. In the investigation reported here, the presence of added epinephrine and norepinephrine in red cells in vitro was determined by means of their reaction with the intracellular non-protein sulphydryl group. To measure the sulphydryl group within erythrocytes the intracellular protein was first denatured by the addition of trichloroacetic acid3,4. Epinephrine within the cells reacted with and decreased the concentration of the free non-protein sulphydryl group with the aid of oxygen liberated during the denaturation of oxyhaemoglobin, while extracellular catecholamine was unreactive. The results indicated that entrance into human erythrocytes was a possible pathway for catecholamine metabolism.
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ROSTON, S. Entrance of Epinephrine into the Human Erythrocyte. Nature 212, 1380–1381 (1966). https://doi.org/10.1038/2121380a0
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DOI: https://doi.org/10.1038/2121380a0
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