Abstract
THE administration of glucocorticoids to rats or other mammals causes an increase in several enzyme activities in the liver, but this is suppressed if the animal is simultaneously given puromycin, ethionine or actinomycin D (refs. 1 and 2). Thus it seems clear that increased activity reflects an increase in the concentration of enzyme, which in turn is dependent on the synthesis of RNA.
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OTTOLENGHI, C., ROMANO, B. & BARNABEI, O. Reduced Breakdown of Rat Liver Microsomal Ribonucleic Acid after Administration of Cortisone. Nature 212, 1267–1268 (1966). https://doi.org/10.1038/2121267a0
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DOI: https://doi.org/10.1038/2121267a0
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