Letter | Published:

Viral Inhibitory Activity of Polyvinylpyrrolidone

Nature volume 212, pages 101102 (01 October 1966) | Download Citation

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Abstract

POLYVINYLPYRROLIDONE (PVP), a commercial organic chemical which bears a close physical resemblance to plasma protein, has been found to have a strong inhibitory action on viruses without appearing significantly toxic to animals. Cells pretreated with PVP showed resistance to infection with herpes simplex and vaccinia viruses in vitro. No effects were observed which could be put down to direct inactivation or neutralization of the infectivity of the viruses.

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Affiliations

  1. Variety Children's Research Foundation and the School of Medicine, University of Miami.

    • BARRY S. MICHAELS
    • , GLENN H. WADDELL
    • , DORAN D. ZINNER
    •  & M. MICHAEL SIGEL

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https://doi.org/10.1038/212101a0

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