Letter | Published:

Effect of Actinomycin D and Halogenated Deoxyuridines on the Replication of Bittner Virus in vitro

Nature volume 212, pages 100101 (01 October 1966) | Download Citation

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Abstract

THE mouse mammary tumour virus (MTV)—or Bittner virus—is an RNA virus containing lipid1 which seems to multiply in the cytoplasm of infected cells and to be released by a budding process of the plasma membrane. Virus is released continuously without causing death of the cells. It appears that in its interaction with the cell, the virus becomes part of a steady-state complex of the type defined by Dulbecco2. It was of interest to determine whether viral replication, under the conditions in the steady-state interaction, required the participation of functional DNA—such as appears to occur with the Rous sarcoma virus3,4, a moderate, lipid-containing RNA tumour virus—or whether, as with most RNA viruses, replication was not dependent on DNA.

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Author information

Author notes

    • MICHAEL J. LYONS

    Present address: Department of Microbiology, University of Pennsylvania, School of Medicine, Philadelphia.

Affiliations

  1. The Rockefeller University, New York, and College of Physicians and Surgeons, Columbia University, New York.

    • MICHAEL J. LYONS
    • , ETIENNE Y. LASFARGUES
    •  & PAUL E. CAME

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DOI

https://doi.org/10.1038/212100a0

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