Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Inhibitory Effect of Chlorpromazine on Alterations in Electroencephalograms induced by Lysergic Acid Diethylamide in Dogs

Abstract

IN the past decade the derivatives of phenothiazine (for example, chlorpromazine), among other tranquillizing drugs, have taken an important role in the palliative treatment of spontaneous psychosis1–4, especially schizophrenia, as well as in the treatment of the acute reversible psychosis, experimentally induced in volunteers and animals, by psychotomimetic drugs such as lysergic acid diethylamide (LSD-25)5–8.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Bradley, P. B., Physiological Pharmacology, 1, 460 (Academic Press, New York, 1963).

    Google Scholar 

  2. Himwich, H. E., J. Neuropsychiatry, 3, 279 (1962).

    Google Scholar 

  3. Killam, K. F., et al. Neuropharmacology, Trans. of the Fifth Conf., N.Y., Josiah Macy, jun., Foundation, 131 (1960).

  4. Sokoloff, L., Pharmacol. Revs., 11, 1 (1959).

    CAS  Google Scholar 

  5. Mayer-Gross, W., et al., Nature, 168, 827 (1951).

    Article  ADS  CAS  Google Scholar 

  6. Himwich, H. E., et al., Neuropsychopharmacology, 329 (Elsevier Pub. Co., 1959).

    Google Scholar 

  7. Key, B. J., Nature, 190, 275 (1961).

    Article  ADS  CAS  Google Scholar 

  8. Nieschulz, O., et al., Arzneimittel-Forsch., 10, 156 (1960).

    CAS  Google Scholar 

  9. Ellingson, R. J., Amer. J. Physiol., 111, 263 (1955).

    Google Scholar 

  10. Goldstein, L., et al., Clin. Pharmacol. and Therap., 4–1 : 10 (1963).

  11. Guiti, N., et al., Electroenceph. Clin. Neurophysiol., 21, 80 (1966).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

DJAHANGUIRI, B., GUITI, N. Inhibitory Effect of Chlorpromazine on Alterations in Electroencephalograms induced by Lysergic Acid Diethylamide in Dogs. Nature 212, 87–88 (1966). https://doi.org/10.1038/212087b0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/212087b0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing