Letter | Published:

Contrasting Endocrine Activities of cis and trans Isomers in a Series of Substituted Triphenylethylenes

Naturevolume 212page87 (1966) | Download Citation



ALTHOUGH triphenylethylene1,2 and many substituted triphenylethylenes3 are known to be oestrogenic, more complex endocrine activity has been encountered in some of its basic derivatives. A notable example is clomiphene, 1-(p-diethylaminoethoxyphenyl)-1,2-diphenyl-2-chloro-ethylene (citrate)4, which has the unexpected property of stimulating ovulation in women with ovulatory failure of certain types5,6.

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  1. 1

    Robson, J. M., and Schönberg, A., Nature, 140, 196 (1937).

  2. 2

    Dodds, C. E., Fitzgerald, M. E. H., and Lawson, W., Nature, 140, 772 (1937).

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    Grundy, J., Chem. Rev., 57, 281 (1957).

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    Holtkamp, D. E., Greslin, J. G., Root, C. A., and Lerner, L. J., Proc. Soc. Exp. Biol. N.Y., 105, 197 (1960).

  5. 5

    Greenblatt, R. B., Fertil. Steril., 12, 402 (1961).

  6. 6

    Kistner, R. W., Obstet. Gynec. Survey, 20, 873 (1965).

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    U.K. Patent No. 1,013,907.

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    U.K. patent application No. 30755/65. Bedford, G. R., and Richardson, D. N., Nature (in the press).

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    Harper, M. J. K., and Walpole, A. L., J. Reprod. Fertil. (in press).

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  1. Research Department, Imperial Chemical Industries, Ltd., Pharmaceuticals Division, Alderley Park, Macclesfield, Cheshire

    • M. J. K. HARPER
    •  & A. L. WALPOLE


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