Letter | Published:

Contrasting Endocrine Activities of cis and trans Isomers in a Series of Substituted Triphenylethylenes

Nature volume 212, page 87 (01 October 1966) | Download Citation

Subjects

Abstract

ALTHOUGH triphenylethylene1,2 and many substituted triphenylethylenes3 are known to be oestrogenic, more complex endocrine activity has been encountered in some of its basic derivatives. A notable example is clomiphene, 1-(p-diethylaminoethoxyphenyl)-1,2-diphenyl-2-chloro-ethylene (citrate)4, which has the unexpected property of stimulating ovulation in women with ovulatory failure of certain types5,6.

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References

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    , , , and , Proc. Soc. Exp. Biol. N.Y., 105, 197 (1960).

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    , Fertil. Steril., 12, 402 (1961).

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    , Obstet. Gynec. Survey, 20, 873 (1965).

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    U.K. Patent No. 1,013,907.

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    U.K. patent application No. 30755/65. , and , Nature (in the press).

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    , and , J. Reprod. Fertil. (in press).

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Author information

Affiliations

  1. Research Department, Imperial Chemical Industries, Ltd., Pharmaceuticals Division, Alderley Park, Macclesfield, Cheshire.

    • M. J. K. HARPER
    •  & A. L. WALPOLE

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https://doi.org/10.1038/212087a0

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