Letter | Published:

Dependence of Insulin Haemagglutination Antibody Titres on IgM Antibody

Nature volume 212, page 84 (01 October 1966) | Download Citation

Subjects

Abstract

SINCE Moinat's1 investigations of haemagglutination antibody titres to insulin, it has been assumed that there is no relationship between insulin requirements and antibody titres except in some cases of insulin resistance. These observations were partly supported by Berson and Yalow2, although these authors did find insulin binding capacities ranging from 50 to 500 units/litre in insulin-resistant patients. Recent investigations in this laboratory3 on variations in insulin requirements in human subjects with differing species of insulin suggested that antibodies to insulin play a significant role in determining insulin requirements even in non-resistant subjects. It was important, therefore, to re-investigate the haemagglutination studies in order to determine whether they reflected a true picture of insulin antibody titres or whether they might be IgM antibody dependent4,5.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    , Diabetes, 7, 462 (1958).

  2. 2.

    , and , J. Clin. Invest., 38, 1996 (1959).

  3. 3.

    , and , Metabolism, 14, 1034 (1964).

  4. 4.

    , Nature, 206, 1368 (1965).

  5. 5.

    , , , and , Proc. Soc. Exp. Biol. and Med., 120, 340 (1965).

Download references

Author information

Affiliations

  1. Department of Medicine, University College, Dublin.

    • JAMES G. DEVLIN
    •  & MARK LAHER

Authors

  1. Search for JAMES G. DEVLIN in:

  2. Search for MARK LAHER in:

About this article

Publication history

Published

DOI

https://doi.org/10.1038/212084a0

Further reading Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.