Letter | Published:

Adherence of Latex Particles to Platelets

Nature volume 212, pages 7980 (01 October 1966) | Download Citation



WHEN platelets in citrated plasma are exposed to latex (polystyrene) particles, the particles adhere to the platelets1 and are phagocytosed by them2. In association with this process, the platelets undergo clumping. Both the phagocytosis and the aggregation depend on the presence of divalent cations, as they are inhibited by the sodium salt of ethylenediaminetetraacetic acid (EDTA). It seemed important, then, to determine whether the initial adherence between particles and platelets was also dependent on the presence of divalent cations.

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  1. 1.

    , , , and , J. Lab. Clin. Med., 65, 179 (1965).

  2. 2.

    , , , and , Cell Biol. (in the press).

  3. 3.

    , and , Biochem. J., 89, 150 (1963).

  4. 4.

    , Thromb. et Diath. Hemorrh., 9, 264 (1963).

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    , and , Thromb. et Diath. Hemorrh., 11, 327 (1964).

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    • M. F. GLYNN

    From the National Heart Institute, National Institutes of Health, Bethesda, Maryland.


  1. Blood and Vascular Disease Research Unit, Departments of Medicine and Pathology, University of Toronto, and Sunnybrook Hospital, Department of Veterans Affairs, Toronto.

    • M. F. GLYNN
    • , R. HERREN
    •  & J. F. MUSTARD


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