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Adherence of Latex Particles to Platelets

Abstract

WHEN platelets in citrated plasma are exposed to latex (polystyrene) particles, the particles adhere to the platelets1 and are phagocytosed by them2. In association with this process, the platelets undergo clumping. Both the phagocytosis and the aggregation depend on the presence of divalent cations, as they are inhibited by the sodium salt of ethylenediaminetetraacetic acid (EDTA). It seemed important, then, to determine whether the initial adherence between particles and platelets was also dependent on the presence of divalent cations.

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References

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GLYNN, M., HERREN, R. & MUSTARD, J. Adherence of Latex Particles to Platelets. Nature 212, 79–80 (1966). https://doi.org/10.1038/212079a0

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