Letter | Published:

Development of the Intestinal Digestion Mechanism of Starch as a Function of Age in Rats

Naturevolume 212pages7879 (1966) | Download Citation



BAKER et al.1 have shown that the villeous architecture of the rat intestinal mucosa flattens out with increasing age. They have demonstrated that the true villi structure, present at birth throughout the intestine, gradually vanishes as the animals grow older. In adult rats they observed only parallel ridges without any projection into the lumen. During this ageing process, the total surface of the intestinal wall steadily diminishes and it is to be expected that there is a concomitant decrease in the digestive and absorptive capacity of the intestinal membrane.

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  1. 1

    Baker, S. J., Mathan, V. I., and Cherian, V., Lancet, i, 860 (1963).

  2. 2

    Ugolev, A. M., Bull. Exp. Biol. and Med., 49, 1 (1960).

  3. 3

    Ugolev, A. M., Nature, 188, 588 (1960).

  4. 4

    De Laey, P., and Jesuitova, N. N., Dokl. Akad. Nauk U.S.S.R., 146, 731 (1962).

  5. 5

    Jesuitova, N. N., De Laey, P., and Ugolev, A. M., Biochim. Biophys. Acta, 86, 205 (1964).

  6. 6

    Hooft, C., Van Hauwaert, J., De Laey, P., and Adriaenssens, K., Helv. Paed. Acta, 18, 502 (1963).

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    • P. DE LAEY

    Present address: Rega Institute for Medical Research, University of Louvain, Belgium


  1. Paediatric Institute, State University of Ghent

    • P. DE LAEY


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